ELIMINATION OF NEGATIVE FEEDBACK IN TLR SIGNALLING ALLOWS RAPID AND HYPERSENSITIVE DETECTION OF MICROBIAL CONTAMINANTS

Elimination of negative feedback in TLR signalling allows rapid and hypersensitive detection of microbial contaminants

Abstract The exquisite specificity of Toll-like receptors (TLRs) to sense microbial molecular signatures is used as a powerful tool to pinpoint microbial contaminants.Various cellular systems, from native human blood cells to transfected cell lines exploit TLRs as pyrogen detectors in biological preparations.However, slow cellular responses and lim

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A systematic review of treatment for impulsivity and compulsivity

Scarves IntroductionThe aim of this study was to comprehensively review existing treatments for impulsivity and compulsivity in non-substance addictions, driven by the importance of these factors in addictive disorder development and treatment efficacy.MethodsA systematic review carried out following PRISMA guidelines identified 14 articles from a

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Treatment of Gastrointestinal Bleeding in the Biliopancreatic Limb with Embolization in a Patient with Duodenal Switch Anatomy

Introduction: Biliopancreatic diversion with duodenal switch (BPD/DS) is an uncommon type of bariatric surgery that can rarely lead to bleeding in the biliopancreatic limb.The altered anatomy poses significant diagnostic and therapeutic challenges.Case Presentation: We present an unusual case of a woman CalExotics status post-BPD/DS nearly a decade

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Human exposure to anopheline mosquitoes occurs primarily indoors, even for users of insecticide-treated nets in Luangwa Valley, South-east Zambia

Abstract Background Current front line malaria vector control methods such as indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs), rely upon the preference of many primary vectors to feed and/or rest inside human habitations where they can be targeted with domestically-applied insecticidal products.We studied the human biting

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