Elimination of negative feedback in TLR signalling allows rapid and hypersensitive detection of microbial contaminants
Abstract The exquisite specificity of Toll-like receptors (TLRs) to sense microbial molecular signatures is used as a powerful tool to pinpoint microbial contaminants.Various cellular systems, from native human blood cells to transfected cell lines exploit TLRs as pyrogen detectors in biological preparations.However, slow cellular responses and lim